A stimulating way to improve T cell responses to poxvirus-vectored vaccines
Stuart N. Isaacs
Stuart N. Isaacs
Published January 4, 2011; First published December 22, 2010
Citation Information: J Clin Invest. 2011;121(1):19-21. https://doi.org/10.1172/JCI45726.
View: Text | PDF
Category: Commentary

A stimulating way to improve T cell responses to poxvirus-vectored vaccines

Abstract

Vaccines remain one of the most cost-effective public health measures. Despite ongoing efforts, protective vaccines against cancer and many infectious diseases, including malaria, tuberculosis, and HIV/AIDS, are still not in hand. Most investigators believe that to succeed against these difficult targets, vaccines that generate potent T cell responses are needed. In this issue of the JCI, Salek-Ardakani et al. show how the relative virulence of a virus/vaccine vector affects the memory CD8+ T cells generated and how the response may be enhanced. The work has important implications for the development of future vaccines that aim to trigger CD8+ T cell responses.

Authors

Stuart N. Isaacs

×

Figure 1

Viral virulence results in enhanced CD8+ T cell memory responses.

Options: View larger image (or click on image) Download as PowerPoint
Viral virulence results in enhanced CD8+ T cell memory responses. Co...
Compared with vaccination with a more attenuated virus (bottom), vaccination with a more virulent virus (top) causes stimulation of OX40 and CD27, which results in larger pools of effector and memory CD8+ T cells that can protect from subsequent lethal challenge.