HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS WITH …
M Trissal, L Mayr, K Schwark, J LaBelle, S Kong… - Neuro …, 2023 - academic.oup.com
BACKGROUND Pediatric high-grade gliomas (PHGG) are aggressive, undifferentiated
central nervous system (CNS) tumors. PHGG comprises subtypes that differ phenotypically,
histologically and by cellular composition. Despite intensive research, overall survival rates
have remained for decades around 2% for diffuse midline glioma (DMG) and 20% for non-
DMG PHGG. We hypothesized that PHGG's heterogeneity, a key difficulty in devising
therapies, results from functional and lineage differences in tumor cell types. METHODS …
central nervous system (CNS) tumors. PHGG comprises subtypes that differ phenotypically,
histologically and by cellular composition. Despite intensive research, overall survival rates
have remained for decades around 2% for diffuse midline glioma (DMG) and 20% for non-
DMG PHGG. We hypothesized that PHGG's heterogeneity, a key difficulty in devising
therapies, results from functional and lineage differences in tumor cell types. METHODS …
[CITATION][C] ABSTRACT CITATION ID: NOAD073. 168 HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG …
M Trissal, L Mayr, K Schwark, J LaBelle… - NEURO …, 2023 - europepmc.org
ABSTRACT CITATION ID: NOAD073. 167 HGG-18. SINGLE CELL RNA-SEQ ANALYSIS OF
PEDIATRIC HIGHGRADE GLIOMA PATIENT SAMPLES IDENTIFIES COMMON GLIAL AND
IMMUNE CELL TYPES THAT HELP TO EXPLAIN HETEROGENEITY AND
TUMORIGENESIS.
PEDIATRIC HIGHGRADE GLIOMA PATIENT SAMPLES IDENTIFIES COMMON GLIAL AND
IMMUNE CELL TYPES THAT HELP TO EXPLAIN HETEROGENEITY AND
TUMORIGENESIS.