Targeting ACC for NASH resolution
A recent paper published in Nature Medicine by Calle et al. reported anti-nonalcoholic
steatohepatitis (NASH) efficiencies by acetyl-CoA carboxylase (ACC) 1/2 inhibitors alone or
by co-administration with a ACC1/2 inhibitor and a diacylglycerol acyltransferase 2 (DGAT2)
inhibitor. Whereas the monotherapy achieved remarkable reductions in liver steatosis but
induced hyperlipidemia, DGAT2 inhibitor co-administration mitigated the increase in serum
triglycerides (TGs).
steatohepatitis (NASH) efficiencies by acetyl-CoA carboxylase (ACC) 1/2 inhibitors alone or
by co-administration with a ACC1/2 inhibitor and a diacylglycerol acyltransferase 2 (DGAT2)
inhibitor. Whereas the monotherapy achieved remarkable reductions in liver steatosis but
induced hyperlipidemia, DGAT2 inhibitor co-administration mitigated the increase in serum
triglycerides (TGs).
A recent paper published in Nature Medicine by Calle et al. reported anti-nonalcoholic steatohepatitis (NASH) efficiencies by acetyl-CoA carboxylase (ACC) 1/2 inhibitors alone or by co-administration with a ACC1/2 inhibitor and a diacylglycerol acyltransferase 2 (DGAT2) inhibitor. Whereas the monotherapy achieved remarkable reductions in liver steatosis but induced hyperlipidemia, DGAT2 inhibitor co-administration mitigated the increase in serum triglycerides (TGs).
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