[HTML][HTML] 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax
M Nomura, S Shimizu, T Sugiyama, M Narita… - Journal of Biological …, 2003 - ASBMB
The Bcl-2 family of proteins comprises well characterized regulators of apoptosis, consisting
of anti-apoptotic members and pro-apoptotic members. Pro-apoptotic members possessing
BH1, BH2, and BH3 domains (such as Bax and Bak) act as a gateway for a variety of
apoptotic signals. Bax is normally localized to the cytoplasm in an inactive form. In response
to apoptotic stimuli, Bax translocates to the mitochondria and undergoes oligomerization to
induce the release of apoptogenic factors such as cytochromec, but it is still largely unknown …
of anti-apoptotic members and pro-apoptotic members. Pro-apoptotic members possessing
BH1, BH2, and BH3 domains (such as Bax and Bak) act as a gateway for a variety of
apoptotic signals. Bax is normally localized to the cytoplasm in an inactive form. In response
to apoptotic stimuli, Bax translocates to the mitochondria and undergoes oligomerization to
induce the release of apoptogenic factors such as cytochromec, but it is still largely unknown …