[HTML][HTML] An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion
H Miyamoto, E Katsuyama, Y Miyauchi, H Hoshi… - Journal of Biological …, 2012 - ASBMB
Macrophage lineage cells such as osteoclasts and foreign body giant cells (FBGCs) form
multinuclear cells by cell-cell fusion of mononuclear cells. Recently, we reported that two
seven-transmembrane molecules, osteoclast stimulatory transmembrane protein (OC-
STAMP) and dendritic cell-specific transmembrane protein (DC-STAMP), were essential for
osteoclast and FBGC cell-cell fusion in vivo and in vitro. However, signaling required to
regulate FBGC fusion remained largely unknown. Here, we show that signal transducer and …
multinuclear cells by cell-cell fusion of mononuclear cells. Recently, we reported that two
seven-transmembrane molecules, osteoclast stimulatory transmembrane protein (OC-
STAMP) and dendritic cell-specific transmembrane protein (DC-STAMP), were essential for
osteoclast and FBGC cell-cell fusion in vivo and in vitro. However, signaling required to
regulate FBGC fusion remained largely unknown. Here, we show that signal transducer and …