Sarcoidosis is a multisystem granulomatous disease with large variability in presentation,
disease behavior, and outcome. The cause of sarcoidosis and explanation for its wide
phenotypic differences are not yet fully understood. Interaction between a presumed trigger
and a genetically susceptible host is considered the mainstay of sarcoidosis pathogenesis.
Genetic factors may play an important role in modifying the risk for the disease, its
phenotype, and the outcome. As a result of the disease heterogeneity, treatment varies from …