Transcriptomic correlates of organ failure extent in sepsis
R Almansa, M Heredia-Rodríguez, E Gomez-Sanchez… - Journal of Infection, 2015 - Elsevier
Objectives Sepsis is characterised by the frequent presence of organ failure and marked
immunologic alterations. We studied the association between the extent of organ failure and
the transcriptomic response of septic patients. Methods Gene expression profiles in the
blood of 74 surgical patients with sepsis were compared with those of 30 surgical patients
with no sepsis. Differentially expressed genes were assessed for their correlation with the
sequential organ failure (SOFA) score. Results The expression levels of a group of genes …
immunologic alterations. We studied the association between the extent of organ failure and
the transcriptomic response of septic patients. Methods Gene expression profiles in the
blood of 74 surgical patients with sepsis were compared with those of 30 surgical patients
with no sepsis. Differentially expressed genes were assessed for their correlation with the
sequential organ failure (SOFA) score. Results The expression levels of a group of genes …