Monocytes have a crucial role in both proinflammatory and anti-inflammatory phenomena
occurring during sepsis. Monocyte recruitment and activation are orchestrated by the
chemokine receptors CX3CR1 and CCR2 and their cognate ligands. However, little is
known about the roles of these cells and chemokines during the acute phase of
inflammation in sepsis. Using intravital microscopy in a murine model of polymicrobial
sepsis, we showed that inflammatory Ly6C high monocytes infiltrated kidneys, exhibited …