Differential alterations of tissue T-cell subsets after sepsis
Among immune cells in responding to sepsis, macrophages and neutrophils have been
extensively studied, while the contribution of T lymphocytes and natural killer T (NKT) cells is
less well characterized. Here we monitored tissue specific changes of T cell subsets in male
C57BL/6 mice subjected to sham operation or cecal ligation and puncture (CLP) to induce
polymicrobial sepsis. Thymus, spleen, liver, lungs and blood were processed and analyzed
20 h later. Total lymphocyte count showed a significant reduction in septic thymus, spleen …
extensively studied, while the contribution of T lymphocytes and natural killer T (NKT) cells is
less well characterized. Here we monitored tissue specific changes of T cell subsets in male
C57BL/6 mice subjected to sham operation or cecal ligation and puncture (CLP) to induce
polymicrobial sepsis. Thymus, spleen, liver, lungs and blood were processed and analyzed
20 h later. Total lymphocyte count showed a significant reduction in septic thymus, spleen …