The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain
WM Babinchak, R Haider, BK Dumm, P Sarkar… - Journal of Biological …, 2019 - ASBMB
Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-
43) is associated with several neurodegenerative disorders, including ALS, frontotemporal
dementia, chronic traumatic encephalopathy, and Alzheimer's disease. TDP-43 aggregation
appears to be largely driven by its low-complexity domain (LCD), which also has a high
propensity to undergo liquid–liquid phase separation (LLPS). However, the mechanism of
TDP-43 LCD pathological aggregation and, most importantly, the relationship between the …
43) is associated with several neurodegenerative disorders, including ALS, frontotemporal
dementia, chronic traumatic encephalopathy, and Alzheimer's disease. TDP-43 aggregation
appears to be largely driven by its low-complexity domain (LCD), which also has a high
propensity to undergo liquid–liquid phase separation (LLPS). However, the mechanism of
TDP-43 LCD pathological aggregation and, most importantly, the relationship between the …
