Rare genetic variants in immune genes and neonatal herpes simplex viral infections
L Cummings, M Tucker, M Gibson, A Myers… - …, 2021 - publications.aap.org
Neonatal herpes simplex virus (HSV) infection is a devastating disease with high mortality,
particularly when disseminated. Studies in adults and children suggest that susceptibility to
herpes simplex encephalitis (HSE) may represent phenotypes for inborn errors in toll-like
receptor 3 (TLR3) signaling. However, the genetic basis of susceptibility to neonatal HSV
including disseminated disease remains unknown. To test the hypothesis that variants in
known HSE-susceptible genes as well as genes mediating HSV immunity will be identified …
particularly when disseminated. Studies in adults and children suggest that susceptibility to
herpes simplex encephalitis (HSE) may represent phenotypes for inborn errors in toll-like
receptor 3 (TLR3) signaling. However, the genetic basis of susceptibility to neonatal HSV
including disseminated disease remains unknown. To test the hypothesis that variants in
known HSE-susceptible genes as well as genes mediating HSV immunity will be identified …