[HTML][HTML] Characterization of FN1–FGFR1 and novel FN1–FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors
JC Lee, SY Su, CA Changou, RS Yang, KS Tsai… - Modern Pathology, 2016 - Elsevier
Phosphaturic mesenchymal tumors typically cause paraneoplastic osteomalacia, chiefly as
a result of FGF23 secretion. In a prior study, we identified FN1–FGFR1 fusion in 9 of 15
phosphaturic mesenchymal tumors. In this study, a total of 66 phosphaturic mesenchymal
tumors and 7 tumors resembling phosphaturic mesenchymal tumor but without known
phosphaturia were studied. A novel FN1–FGF1 fusion gene was identified in two cases
without FN1–FGFR1 fusion by RNA sequencing and cross-validated with direct sequencing …
a result of FGF23 secretion. In a prior study, we identified FN1–FGFR1 fusion in 9 of 15
phosphaturic mesenchymal tumors. In this study, a total of 66 phosphaturic mesenchymal
tumors and 7 tumors resembling phosphaturic mesenchymal tumor but without known
phosphaturia were studied. A novel FN1–FGF1 fusion gene was identified in two cases
without FN1–FGFR1 fusion by RNA sequencing and cross-validated with direct sequencing …