[HTML][HTML] Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO
L Xiao, T Naganawa, J Lorenzo, TO Carpenter… - Journal of Biological …, 2010 - ASBMB
FGF2 transgenic mice were developed in which type I collagen regulatory sequences drive
the nuclear high molecular weight FGF2 isoforms in osteoblasts (TgHMW). The phenotype of
TgHMW mice included dwarfism, decreased bone mineral density (BMD), osteomalacia, and
decreased serum phosphate (P i). When TgHMW mice were fed a high P i diet, BMD was
increased, and dwarfism was partially reversed. The TgHMW phenotype was similar to mice
overexpressing FGF23. Serum FGF23 was increased in TgHMW mice. Fgf23 mRNA in …
the nuclear high molecular weight FGF2 isoforms in osteoblasts (TgHMW). The phenotype of
TgHMW mice included dwarfism, decreased bone mineral density (BMD), osteomalacia, and
decreased serum phosphate (P i). When TgHMW mice were fed a high P i diet, BMD was
increased, and dwarfism was partially reversed. The TgHMW phenotype was similar to mice
overexpressing FGF23. Serum FGF23 was increased in TgHMW mice. Fgf23 mRNA in …
