[HTML][HTML] IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes
CA DeCarlo, A Severini, L Edler, NG Escott… - Laboratory …, 2010 - Elsevier
Interferons (IFNs) are expressed by many cell types and play a pivotal role in the generation
of immune responses against viral infections. IFN-κ, a novel type I IFN, displays a tight
tropism for keratinocytes and specific lymphoid populations and exhibits functional
similarities with other type I IFNs. The human papillomavirus (HPV), the etiological agent for
cervical cancer, infects keratinocytes of the uterine cervix and has been shown to directly
inhibit the IFN pathway. We evaluated IFN-κ,-β, and-γ gene expression in HPV-negative …
of immune responses against viral infections. IFN-κ, a novel type I IFN, displays a tight
tropism for keratinocytes and specific lymphoid populations and exhibits functional
similarities with other type I IFNs. The human papillomavirus (HPV), the etiological agent for
cervical cancer, infects keratinocytes of the uterine cervix and has been shown to directly
inhibit the IFN pathway. We evaluated IFN-κ,-β, and-γ gene expression in HPV-negative …
