Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells
MS Ryu, KA Duck, CC Philpott - Blood Cells, Molecules, and Diseases, 2018 - Elsevier
Developing red blood cells exhibit multiple, redundant systems for regulating and
coordinating the uptake of iron, the synthesis of heme, and the formation of hemoglobin
during terminal differentiation. We recently described the roles of poly rC-binding protein
(PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in
developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and
NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and …
coordinating the uptake of iron, the synthesis of heme, and the formation of hemoglobin
during terminal differentiation. We recently described the roles of poly rC-binding protein
(PCBP1) and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in
developing erythroid cells, with PCBP1, an iron chaperone, delivering iron to ferritin and
NCOA4, an autophagic cargo receptor, directing ferritin to the lysosome for degradation and …