Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas
KJ Busam, AA Jungbluth, N Rekthman… - The American journal …, 2009 - journals.lww.com
Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine
carcinoma. Recently, a new polyoma virus has been identified that is clonally integrated in
the genome of the majority of MCCs, with truncating mutations in the viral large T antigen
gene. We examined the presence of Merkel cell polyomavirus (MCV) in a set of 17 frozen
tumor samples by quantitative polymerase chain reaction; 15 of them (88%) were positive.
Sections from corresponding archival material were analyzed by immunohistochemistry …
carcinoma. Recently, a new polyoma virus has been identified that is clonally integrated in
the genome of the majority of MCCs, with truncating mutations in the viral large T antigen
gene. We examined the presence of Merkel cell polyomavirus (MCV) in a set of 17 frozen
tumor samples by quantitative polymerase chain reaction; 15 of them (88%) were positive.
Sections from corresponding archival material were analyzed by immunohistochemistry …