The remarkable success of cancer immunotherapies, especially the checkpoint blocking
antibodies, in a subset of patients has reinvigorated the study of tumor-immune crosstalk
and its role in heterogeneity of response. High-throughput sequencing and imaging
technologies can help recapitulate various aspects of the tumor ecosystem. Computational
approaches provide an arsenal of tools to efficiently analyze, quantify and integrate multiple
parameters of tumor immunity mined from these diverse but complementary high-throughput …