Characterization of differentiated and dedifferentiated clones from a rat hepatoma
J Deschatrette, MC Weiss - Biochimie, 1975 - Elsevier
An analysis of clonal variability of derivatives of the rat hepatoma line H4IIEC3 has shown
that the overwhelming majority of clones express in a stable fashion a number of liver
specific functions, including secretion of serum albumin, activity of the liver specific isozymes
of alcohol dehydrogenase (EC1. 1.1. 1) and aldolase (EC4. 1.2. 13), and high basal activity
and hormone inducibility of tyrosine aminotransferase (EC2. 6.1. 5) and alanine
aminotransferase (EC2. 6.1. 2). The differences in level of expression of these functions …
that the overwhelming majority of clones express in a stable fashion a number of liver
specific functions, including secretion of serum albumin, activity of the liver specific isozymes
of alcohol dehydrogenase (EC1. 1.1. 1) and aldolase (EC4. 1.2. 13), and high basal activity
and hormone inducibility of tyrosine aminotransferase (EC2. 6.1. 5) and alanine
aminotransferase (EC2. 6.1. 2). The differences in level of expression of these functions …