Integrating metabolism and longevity through insulin and IGF1 signaling
M Sadagurski, MF White - Endocrinology and Metabolism …, 2013 - endo.theclinics.com
Insulin/IGF1 signaling has pleiotropic biological effects in virtually all tissues; however, the
role of insulin/IGF1 signaling in peripheral tissues has been studied far more extensively
than its role in the brain. 1 Reduced insulin signaling, usually called insulin resistance in
clinical circles, has serious detrimental effects that usually lead to excess circulating insulin
and life-threatening metabolic disorders, including type 2 diabetes and cardiovascular
disease. 2 By comparison, genetic strategies to reduce insulin/IGF1 signaling in …
role of insulin/IGF1 signaling in peripheral tissues has been studied far more extensively
than its role in the brain. 1 Reduced insulin signaling, usually called insulin resistance in
clinical circles, has serious detrimental effects that usually lead to excess circulating insulin
and life-threatening metabolic disorders, including type 2 diabetes and cardiovascular
disease. 2 By comparison, genetic strategies to reduce insulin/IGF1 signaling in …