Individuals with CKD are particularly predisposed to thrombosis after vascular injury. Using
mouse models, we recently described indoxyl sulfate, a tryptophan metabolite retained in
CKD and an activator of tissue factor (TF) through aryl hydrocarbon receptor (AHR)
signaling, as an inducer of thrombosis across the CKD spectrum. However, the translation of
findings from animal models to humans is often challenging. Here, we investigated the
uremic solute–AHR–TF thrombosis axis in two human cohorts, using a targeted …