Restrictive chronic lung allograft dysfunction: where are we now?
SE Verleden, D Ruttens, E Vandermeulen… - The Journal of heart and …, 2015 - Elsevier
Chronic lung allograft dysfunction (CLAD) remains a frequent and troublesome complication
after lung transplantation. Apart from bronchiolitis obliterans syndrome (BOS), a restrictive
phenotype of CLAD (rCLAD) has recently been recognized, which occurs in approximately
30% of CLAD patients. The main characteristics of rCLAD include a restrictive pulmonary
function pattern with a persistent decline in lung function (FEV 1, FVC and TLC), persistent
parenchymal infiltrates and (sub) pleural thickening on chest CT scan, as well as …
after lung transplantation. Apart from bronchiolitis obliterans syndrome (BOS), a restrictive
phenotype of CLAD (rCLAD) has recently been recognized, which occurs in approximately
30% of CLAD patients. The main characteristics of rCLAD include a restrictive pulmonary
function pattern with a persistent decline in lung function (FEV 1, FVC and TLC), persistent
parenchymal infiltrates and (sub) pleural thickening on chest CT scan, as well as …
