Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis
Y Geng, Q Ma, YN Liu, N Peng, FF Yuan, XG Li, M Li… - Journal of …, 2015 - Elsevier
Background & Aims Liver injury is a common complication of heat stroke (HS), and often
constitutes a direct cause for patient death. The cellular and molecular mechanism
underlying HS-induced liver injury remains unclear. Recent evidence indicates that
inflammasome plays an important role in mediating sterile inflammation triggered by tissue
damage. Using a rat HS model, we identified a novel mechanism by which inflammasome-
dependent interleukin-1β (IL-1β) activation and hepatocyte pyroptosis mediate HS-induced …
constitutes a direct cause for patient death. The cellular and molecular mechanism
underlying HS-induced liver injury remains unclear. Recent evidence indicates that
inflammasome plays an important role in mediating sterile inflammation triggered by tissue
damage. Using a rat HS model, we identified a novel mechanism by which inflammasome-
dependent interleukin-1β (IL-1β) activation and hepatocyte pyroptosis mediate HS-induced …
