[HTML][HTML] Evaluation of C1q status and titer of de novo donor-specific antibodies as predictors of allograft survival
De novo donor-specific antibodies (dnDSAs) that develop after renal transplantation are
independent predictors of allograft loss. However, it is unknown if dnDSA C1q status or titer
at the time of first detection can independently predict allograft loss. In a consecutive cohort
of 508 renal transplant recipients, 70 developed dnDSAs. Histologic and clinical outcomes
were correlated with the C1q assay or dnDSA titer. C1q positivity correlated with dnDSA titer
(p< 0.01) and mean fluorescence intensity (p< 0.01) and was more common in class II …
independent predictors of allograft loss. However, it is unknown if dnDSA C1q status or titer
at the time of first detection can independently predict allograft loss. In a consecutive cohort
of 508 renal transplant recipients, 70 developed dnDSAs. Histologic and clinical outcomes
were correlated with the C1q assay or dnDSA titer. C1q positivity correlated with dnDSA titer
(p< 0.01) and mean fluorescence intensity (p< 0.01) and was more common in class II …