Antibody ligation of human leukocyte antigen class I molecules stimulates migration and proliferation of smooth muscle cells in a focal adhesion kinase–dependent …
F Li, X Zhang, YP Jin, A Mulder, EF Reed - Human immunology, 2011 - Elsevier
Chronic rejection manifests as transplant vasculopathy, which is characterized by intimal
thickening of the vessels of the allograft. Intimal thickening is thought to result from the
migration and proliferation of vascular smooth muscle cells (SMC) in the vessel media,
followed by deposition of extracellular matrix proteins. The development of post-
transplantation anti–human leukocyte antigen (HLA) antibodies (Ab) is strongly correlated
with the development of transplant vasculopathy and graft loss. Here we demonstrate that …
thickening of the vessels of the allograft. Intimal thickening is thought to result from the
migration and proliferation of vascular smooth muscle cells (SMC) in the vessel media,
followed by deposition of extracellular matrix proteins. The development of post-
transplantation anti–human leukocyte antigen (HLA) antibodies (Ab) is strongly correlated
with the development of transplant vasculopathy and graft loss. Here we demonstrate that …