[HTML][HTML] Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids

L Parente - BMC Pharmacology and Toxicology, 2017 - Springer
L Parente
BMC Pharmacology and Toxicology, 2017Springer
Background Deflazacort is a synthetic corticosteroid characterized by a favourable
pharmacokinetic profile, peculiar pharmacodynamic properties and a good safety profile.
However, to the best of our knowledge, no dose-conversion table based on direct
comparison of relative potencies between deflazacort and other main corticosteroids is
currently available in scientific literature. Main body This paper, while reporting a brief
review of deflazacort pharmacological properties, its efficacy and tolerability in different …
Background
Deflazacort is a synthetic corticosteroid characterized by a favourable pharmacokinetic profile, peculiar pharmacodynamic properties and a good safety profile. However, to the best of our knowledge, no dose-conversion table based on direct comparison of relative potencies between deflazacort and other main corticosteroids is currently available in scientific literature.
Main body
This paper, while reporting a brief review of deflazacort pharmacological properties, its efficacy and tolerability in different clinical areas, has been designed with the specific aim of providing a new dose-conversion table of corticosteroids, including for the first time also deflazacort.
Short conclusion
We suggest that this new conversion table could be a useful tool for physicians who need to select the appropriate dose of deflazacort in their clinical practice.
Springer