[HTML][HTML] Role of group 1 CD1-restricted T cells in infectious disease

S Siddiqui, L Visvabharathy, CR Wang - Frontiers in immunology, 2015 - frontiersin.org
S Siddiqui, L Visvabharathy, CR Wang
Frontiers in immunology, 2015frontiersin.org
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid
antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC
molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive
vaccine targets that could be recognized in a genetically diverse human population. Group 1
CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in
a variety of autoimmune and infectious diseases. In this review, we summarize current …
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive vaccine targets that could be recognized in a genetically diverse human population. Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in a variety of autoimmune and infectious diseases. In this review, we summarize current knowledge and recent discoveries on the development of group 1 CD1-restricted T cells and their function in different infection models. In particular, we focus on (1) newly identified microbial and self-lipid antigens, (2) kinetics, phenotype, and unique properties of group 1 CD1-restricted T cells during infection, and (3) the similarities of group 1 CD1-restricted T cells to the closely related group 2 CD1-restricted T cells.
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