Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat
A Pitkänen, I Kharatishvili, S Narkilahti, K Lukasiuk… - Epilepsy research, 2005 - Elsevier
Prevention of epileptogenesis after brain insults, such as status epilepticus (SE), head
trauma, or stroke, remains a challenge. Even if epilepsy cannot be prevented, it would be
beneficial if the pathologic process could be modified to result in a less severe disease. We
examined whether early discontinuation of SE reduces the risk of epilepsy or results in
milder disease. Epileptogenesis was triggered with SE induced by electrical stimulation of
the amygdala. Animals (n= 72) were treated with vehicle or diazepam (DZP, 20mg/kg) 2h or …
trauma, or stroke, remains a challenge. Even if epilepsy cannot be prevented, it would be
beneficial if the pathologic process could be modified to result in a less severe disease. We
examined whether early discontinuation of SE reduces the risk of epilepsy or results in
milder disease. Epileptogenesis was triggered with SE induced by electrical stimulation of
the amygdala. Animals (n= 72) were treated with vehicle or diazepam (DZP, 20mg/kg) 2h or …