The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions

GJ Clark, X Ju, C Tate, DNJ Hart - Trends in immunology, 2009 - cell.com
GJ Clark, X Ju, C Tate, DNJ Hart
Trends in immunology, 2009cell.com
The CD300 glycoproteins are a family of cell surface molecules that modulate a diverse
array of cell processes via their paired triggering and inhibitory receptor functions. Family
members share a common evolutionary pathway and at least one member of the family has
undergone significant positive selection, indicating their crucial value to the host. This review
clarifies the occasionally confusing usage of nomenclature for the CD300 family and
summarizes our current understanding of their genomics, expression and function. Their …
The CD300 glycoproteins are a family of cell surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. Family members share a common evolutionary pathway and at least one member of the family has undergone significant positive selection, indicating their crucial value to the host. This review clarifies the occasionally confusing usage of nomenclature for the CD300 family and summarizes our current understanding of their genomics, expression and function. Their ability to fine tune leukocyte function and immune responses highlights several potential options to exploit the CD300 molecules as therapeutic targets in chronic inflammatory diseases, allergy and other disease states.
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