Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
L Shi, N Tu, PH Patterson - International Journal of Developmental …, 2005 - Elsevier
Epidemiological studies have shown that maternal infection can increase the risk for mental
illness in the offspring. In a mouse model of maternal respiratory infection with influenza
virus, the adult offspring display striking behavioral, pharmacological and histological
abnormalities. Although influenza primarily infects the respiratory system, there are reports
of viral mRNA and protein in the fetus of infected pregnant animals. To determine the extent
of viral spread following maternal respiratory infection, we used RT–PCR to assay various …
illness in the offspring. In a mouse model of maternal respiratory infection with influenza
virus, the adult offspring display striking behavioral, pharmacological and histological
abnormalities. Although influenza primarily infects the respiratory system, there are reports
of viral mRNA and protein in the fetus of infected pregnant animals. To determine the extent
of viral spread following maternal respiratory infection, we used RT–PCR to assay various …