Antibody recognition of carbohydrate epitopes

O Haji-Ghassemi, RJ Blackler, N Martin Young… - …, 2015 - academic.oup.com
O Haji-Ghassemi, RJ Blackler, N Martin Young, SV Evans
Glycobiology, 2015academic.oup.com
Carbohydrate antigens are valuable as components of vaccines for bacterial infectious
agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics
against cancer. The crystal structures of anti-carbohydrate antibodies in complex with
antigen reveal the key features of antigen recognition and provide information that can guide
the design of vaccines, particularly synthetic ones. This review summarizes structural
features of anti-carbohydrate antibodies to over 20 antigens, based on six categories of …
Abstract
Carbohydrate antigens are valuable as components of vaccines for bacterial infectious agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics against cancer. The crystal structures of anti-carbohydrate antibodies in complex with antigen reveal the key features of antigen recognition and provide information that can guide the design of vaccines, particularly synthetic ones. This review summarizes structural features of anti-carbohydrate antibodies to over 20 antigens, based on six categories of glyco-antigen: (i) the glycan shield of HIV glycoproteins; (ii) tumor epitopes; (iii) glycolipids and blood group A antigen; (iv) internal epitopes of bacterial lipopolysaccharides; (v) terminal epitopes on polysaccharides and oligosaccharides, including a group of antibodies to Kdo-containing Chlamydia epitopes; and (vi) linear homopolysaccharides.
Oxford University Press