Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice
R Kimura, N Takahashi, T Goto, K Murota… - Obesity Research & …, 2013 - Elsevier
Postprandial lipidemia is a risk factor for cardiovascular diseases. Thus, the suppression of
postprandial lipidemia is valuable for disease management. Peroxisome proliferator-
activated receptor-α (PPARα) is a key regulator in the lipid metabolism of peripheral tissues
such as the liver and skeletal muscle, whose activation enhances fatty acid oxidation and
decreases circulating lipid level. Recently, we have shown that bezafibrate, an agonistic
compound for PPARα, suppresses postprandial lipidemia by enhancing fatty acid oxidation …
postprandial lipidemia is valuable for disease management. Peroxisome proliferator-
activated receptor-α (PPARα) is a key regulator in the lipid metabolism of peripheral tissues
such as the liver and skeletal muscle, whose activation enhances fatty acid oxidation and
decreases circulating lipid level. Recently, we have shown that bezafibrate, an agonistic
compound for PPARα, suppresses postprandial lipidemia by enhancing fatty acid oxidation …