[HTML][HTML] Peroxisome proliferator-activated receptor-γ activation augments the β-cell unfolded protein response and rescues early glycemic deterioration and β cell …
Type 1 diabetes is an autoimmune disorder that is characterized by a failure of the unfolded
protein response in islet β cells with subsequent endoplasmic reticulum stress and cellular
death. Thiazolidinediones are insulin sensitizers that activate the nuclear receptor PPAR-γ
and have been shown to partially ameliorate autoimmune type 1 diabetes in humans and
non-obese diabetic (NOD) mice. We hypothesized that thiazolidinediones reduce β cell
stress and death independently of insulin sensitivity. To test this hypothesis, female NOD …
protein response in islet β cells with subsequent endoplasmic reticulum stress and cellular
death. Thiazolidinediones are insulin sensitizers that activate the nuclear receptor PPAR-γ
and have been shown to partially ameliorate autoimmune type 1 diabetes in humans and
non-obese diabetic (NOD) mice. We hypothesized that thiazolidinediones reduce β cell
stress and death independently of insulin sensitivity. To test this hypothesis, female NOD …