[HTML][HTML] Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes [S]
Peroxisome proliferator-activated receptor-α (PPARα) is a dietary lipid sensor, whose
activation results in hypolipidemic effects. In this study, we investigated whether PPARα
activation affects energy metabolism in white adipose tissue (WAT). Activation of PPARα by
its agonist (bezafibrate) markedly reduced adiposity in KK mice fed a high-fat diet. In 3T3-L1
adipocytes, addition of GW7647, a highly specific PPARα agonist, during adipocyte
differentiation enhanced glycerol-3-phosphate dehydrogenase activity, insulin-stimulated …
activation results in hypolipidemic effects. In this study, we investigated whether PPARα
activation affects energy metabolism in white adipose tissue (WAT). Activation of PPARα by
its agonist (bezafibrate) markedly reduced adiposity in KK mice fed a high-fat diet. In 3T3-L1
adipocytes, addition of GW7647, a highly specific PPARα agonist, during adipocyte
differentiation enhanced glycerol-3-phosphate dehydrogenase activity, insulin-stimulated …