Selective modulation of PPARγ activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes
FL Dunn, LS Higgins, J Fredrickson, AM DePaoli… - Journal of Diabetes and …, 2011 - Elsevier
OBJECTIVE: INT131 besylate is a potent non-thiazolidinedione selective peroxisome
proliferator-activated receptor γ (PPARγ) modulator (SPPARM) designed to improve insulin
sensitivity and glucose metabolism while minimizing the side effects of full agonist
thiazolidinediones. This study was conducted to determine short-term efficacy and safety of
INT131 besylate in patients with Type 2 diabetes mellitus (T2DM). RESEARCH DESIGN
AND METHODS: This was a 4-week randomized, double-blind, placebo-controlled multi …
proliferator-activated receptor γ (PPARγ) modulator (SPPARM) designed to improve insulin
sensitivity and glucose metabolism while minimizing the side effects of full agonist
thiazolidinediones. This study was conducted to determine short-term efficacy and safety of
INT131 besylate in patients with Type 2 diabetes mellitus (T2DM). RESEARCH DESIGN
AND METHODS: This was a 4-week randomized, double-blind, placebo-controlled multi …