The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and …
N Hennuyer, I Duplan, C Paquet, J Vanhoutte… - Atherosclerosis, 2016 - Elsevier
Background Atherosclerosis is characterized by lipid accumulation and chronic inflammation
in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a
risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high-
density lipoprotein (HDL) and apoA-I are protective against CVD by enhancing reverse
cholesterol transport (RCT). Activation of peroxisome proliferator-activated receptor-α
(PPARα), a ligand-activated transcription factor, controls lipid metabolism, cellular …
in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a
risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high-
density lipoprotein (HDL) and apoA-I are protective against CVD by enhancing reverse
cholesterol transport (RCT). Activation of peroxisome proliferator-activated receptor-α
(PPARα), a ligand-activated transcription factor, controls lipid metabolism, cellular …