[HTML][HTML] PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
LA Bojic, DE Telford, MD Fullerton, RJ Ford… - Journal of Lipid …, 2014 - ASBMB
PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid
metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ
agonist corrects hepatic steatosis induced by a high-fat, cholesterol-containing (HFHC) diet.
Ldlr−/− mice were fed a chow or HFHC diet (42% fat, 0.2% cholesterol) for 4 weeks. For an
additional 8 weeks, the HFHC group was fed HFHC or HFHC plus GW1516 (3 mg/kg/day).
GW1516-intervention significantly attenuated liver TG accumulation by induction of FA β …
metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ
agonist corrects hepatic steatosis induced by a high-fat, cholesterol-containing (HFHC) diet.
Ldlr−/− mice were fed a chow or HFHC diet (42% fat, 0.2% cholesterol) for 4 weeks. For an
additional 8 weeks, the HFHC group was fed HFHC or HFHC plus GW1516 (3 mg/kg/day).
GW1516-intervention significantly attenuated liver TG accumulation by induction of FA β …