[HTML][HTML] Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between …
SW Chung, BY Kang, SH Kim, YK Pak, D Cho… - Journal of Biological …, 2000 - ASBMB
Lipopolysaccharide (LPS) increases the production of interleukin-12 (IL-12) from mouse
macrophages via a κB site within the IL-12 p40 promoter. In this study, we found that
oxidized low density lipoprotein (oxLDL) inhibited this LPS-stimulated production of IL-12 in
a dose-dependent manner while native LDL did not. OxLDL inhibited p40 promoter
activation in monocytic RAW264. 7 cells transiently transfected with p40 promoter/reporter
constructs, and the repressive effect mapped to a region in the p40 promoter containing a …
macrophages via a κB site within the IL-12 p40 promoter. In this study, we found that
oxidized low density lipoprotein (oxLDL) inhibited this LPS-stimulated production of IL-12 in
a dose-dependent manner while native LDL did not. OxLDL inhibited p40 promoter
activation in monocytic RAW264. 7 cells transiently transfected with p40 promoter/reporter
constructs, and the repressive effect mapped to a region in the p40 promoter containing a …