CNS GLP-1 regulation of peripheral glucose homeostasis

D Sandoval - Physiology & behavior, 2008 - Elsevier
D Sandoval
Physiology & behavior, 2008Elsevier
Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems
whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose
homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS
that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose
homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the
arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 …
Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 physiology. This review discusses the peripheral and central GLP-1 systems and presents a model whereby these systems are integrated in regulation of glucose homeostasis.
Elsevier