Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues

K Goodarzi, M Goodarzi, AM Tager, AD Luster… - Nature …, 2003 - nature.com
K Goodarzi, M Goodarzi, AM Tager, AD Luster, UH von Andrian
Nature immunology, 2003nature.com
Abstract Leukotriene B4 (LTB4) is a potent chemoattractant for myeloid leukocytes, which
express BLT1, the high-affinity receptor for LTB4. We report here that BLT1 is induced
substantially in CD8+ effector T cells and at lower amounts in CD8+ central memory T cells.
LTB4 elicited BLT1-dependent chemotaxis in effector cells, but not in naive or central
memory cells. Intravital microscopy showed that BLT1 signaling induced rapid integrin-
mediated arrest of rolling effector and central memory cells in postcapillary venules. In …
Abstract
Leukotriene B4 (LTB4) is a potent chemoattractant for myeloid leukocytes, which express BLT1, the high-affinity receptor for LTB4. We report here that BLT1 is induced substantially in CD8+ effector T cells and at lower amounts in CD8+ central memory T cells. LTB4 elicited BLT1-dependent chemotaxis in effector cells, but not in naive or central memory cells. Intravital microscopy showed that BLT1 signaling induced rapid integrin-mediated arrest of rolling effector and central memory cells in postcapillary venules. In competitive homing experiments, wild-type effector cells were three times more efficient at migrating to the inflamed peritoneal cavity than were BLT-deficient effector cells. These results identify LTB4-BLT1 as a potent nonchemokine pathway for cytotoxic effector cell traffic.
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