Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments

M Chen, JV Forrester, H Xu - Experimental eye research, 2007 - Elsevier
Complement activation is thought to be involved in the pathogenesis of age-related macular
degeneration (AMD), in part because certain gene polymorphisms in complement factor H
(CFH), an important regulator of the alternative complement activation pathway, are high risk
factors for AMD. How CFH is regulated locally at the retina/choroid interface and how this
contributes to AMD development remain unknown. In the present study, we have confirmed
that CFH was detectable by immunohistochemistry in the choroid, and at low levels in the …