Early T cell differentiation: Lessons from T-cell acute lymphoblastic leukemia
CS Tremblay, T Hoang, T Hoang - Progress in molecular biology and …, 2010 - Elsevier
T cells develop from bone marrow-derived self-renewing hematopoietic stem cells (HSC).
Upon entering the thymus, these cells undergo progressive commitment and differentiation
driven by the thymic stroma and the pre-T cell receptor (pre-TCR). These processes are
disrupted in T-cell acute lymphoblastic leukemia (T-ALL). More than 70% of recurring
chromosomal rearrangements in T-ALL activate the expression of oncogenic transcription
factors, belonging mostly to three families, basic helix-loop-helix (bHLH), homeobox (HOX) …
Upon entering the thymus, these cells undergo progressive commitment and differentiation
driven by the thymic stroma and the pre-T cell receptor (pre-TCR). These processes are
disrupted in T-cell acute lymphoblastic leukemia (T-ALL). More than 70% of recurring
chromosomal rearrangements in T-ALL activate the expression of oncogenic transcription
factors, belonging mostly to three families, basic helix-loop-helix (bHLH), homeobox (HOX) …