Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria
D Fujisawa, J Kashiwakura, H Kita, Y Kikukawa… - Journal of allergy and …, 2014 - Elsevier
Background Wheal reactions to intradermally injected neuropeptides, such as substance P
(SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients
with chronic urticaria (CU) than in nonatopic control (NC) subjects. Mas-related gene X2
(MrgX2) has been identified as a receptor for basic neuropeptides, such as SP and
vasoactive intestinal peptide. Mast cell (MC) responsiveness to eosinophil mediators
contributes to the late-phase reaction of allergy. Objective We sought to compare the …
(SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients
with chronic urticaria (CU) than in nonatopic control (NC) subjects. Mas-related gene X2
(MrgX2) has been identified as a receptor for basic neuropeptides, such as SP and
vasoactive intestinal peptide. Mast cell (MC) responsiveness to eosinophil mediators
contributes to the late-phase reaction of allergy. Objective We sought to compare the …