Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice
B Schäfer, AM Piliponsky, T Oka, CH Song… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Mast cells express receptors for complement anaphylatoxins C3a and C5a
(ie, C3a receptor [C3aR] and C5a receptor [C5aR]), and C3a and C5a are generated during
various IgE-dependent immediate hypersensitivity reactions in vivo. However, it is not clear
to what extent mast cell expression of C3aR or C5aR influences C3a-or C5a-induced
cutaneous responses or IgE-dependent mast cell activation and passive cutaneous
anaphylaxis (PCA) in vivo. OBJECTIVE: We sought to assess whether mouse skin mast cell …
(ie, C3a receptor [C3aR] and C5a receptor [C5aR]), and C3a and C5a are generated during
various IgE-dependent immediate hypersensitivity reactions in vivo. However, it is not clear
to what extent mast cell expression of C3aR or C5aR influences C3a-or C5a-induced
cutaneous responses or IgE-dependent mast cell activation and passive cutaneous
anaphylaxis (PCA) in vivo. OBJECTIVE: We sought to assess whether mouse skin mast cell …