[HTML][HTML] The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling
R Calvez, F Lafouresse, J De Meester, A Galy… - …, 2011 - ncbi.nlm.nih.gov
haematologica, 2011•ncbi.nlm.nih.gov
Background T-cell activation relies on the assembly of the immunological synapse, a
structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich
syndrome protein, an actin cytoskeleton regulator, in linking immunological synapse
structure to downstream signaling remains to be clarified.
structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich
syndrome protein, an actin cytoskeleton regulator, in linking immunological synapse
structure to downstream signaling remains to be clarified.
Abstract
Background
T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological synapse structure to downstream signaling remains to be clarified.
ncbi.nlm.nih.gov