More than a quarter of a century has passed since the observation that T cells rapidly
polarize their actin and microtubule cytoskeletal systems toward antigen‐presenting cells
during activation. Since this initial discovery, several receptors on T cells (eg, T cell receptor
[TCR], co‐receptors, integrins, and chemokine receptors) have been identified to regulate
these two cytoskeletal networks through complex signaling pathways, which are still being
elucidated. There is now an undeniable body of biochemical, pharmacological, and genetic …