Ectopic fat accumulation has been linked to lipotoxic events, including the development of
insulin resistance in skeletal muscle. Indeed, intramyocellular lipid storage is strongly
associated with the development of type 2 diabetes. Research during the last two decades
has provided evidence for a role of lipid intermediates like diacylglycerol and ceramide in
the induction of lipid-induced insulin resistance. However, recently novel data has been
gathered that suggest that the relation between lipid intermediates and insulin resistance is …