[HTML][HTML] The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule
YC Liu, Z Chen, SR Burrows, AW Purcell… - Journal of Biological …, 2012 - ASBMB
Although the major histocompatibility complex class I (MHC-I) molecules typically bind short
peptide (p) fragments (8–10 amino acids in length), longer," bulged" peptides are often be
presented by MHC-I. Such bulged pMHC-I complexes represent challenges for T-cell
receptor (TCR) ligation, although the general principles underscoring the interaction
between TCRs and bulged pMHC-I complexes are unclear. To address this, we have
explored the energetic basis of how an immunodominant TCR (termed SB27) binds to a 13 …
peptide (p) fragments (8–10 amino acids in length), longer," bulged" peptides are often be
presented by MHC-I. Such bulged pMHC-I complexes represent challenges for T-cell
receptor (TCR) ligation, although the general principles underscoring the interaction
between TCRs and bulged pMHC-I complexes are unclear. To address this, we have
explored the energetic basis of how an immunodominant TCR (termed SB27) binds to a 13 …