[HTML][HTML] Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor
CD8+ T-cells specific for MART-1-(26–35), a dominant melanoma epitope restricted by
human leukocyte antigen (HLA)-A* 0201, are exceptionally common in the naive T-cell
repertoire. Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor α (TCRα)
chain in> 87% of these T-cells. Here, the molecular basis for this genetic bias is revealed
from the structural and thermodynamic properties of an archetypal TRAV12-2-encoded TCR
complexed to the clinically relevant heteroclitic peptide, ELAGIGILTV, bound to HLA-A* 0201 …
human leukocyte antigen (HLA)-A* 0201, are exceptionally common in the naive T-cell
repertoire. Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor α (TCRα)
chain in> 87% of these T-cells. Here, the molecular basis for this genetic bias is revealed
from the structural and thermodynamic properties of an archetypal TRAV12-2-encoded TCR
complexed to the clinically relevant heteroclitic peptide, ELAGIGILTV, bound to HLA-A* 0201 …