[HTML][HTML] GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity
S Ezoe, I Matsumura, K Gale, Y Satoh… - Journal of Biological …, 2005 - ASBMB
Although GATA-1 and GATA-2 were shown to be essential for the development of
hematopoietic cells by gene targeting experiments, they were also reported to inhibit the
growth of hematopoietic cells. Therefore, in this study, we examined the effects of GATA-1
and GATA-2 on cytokine signals. A tamoxifen-inducible form of GATA-1 (GATA-1/ERT)
showed a minor inhibitory effect on interleukin-3 (IL-3)-dependent growth of an IL-3-
dependent cell line Ba/F3. On the other hand, it drastically inhibited TPO-dependent growth …
hematopoietic cells by gene targeting experiments, they were also reported to inhibit the
growth of hematopoietic cells. Therefore, in this study, we examined the effects of GATA-1
and GATA-2 on cytokine signals. A tamoxifen-inducible form of GATA-1 (GATA-1/ERT)
showed a minor inhibitory effect on interleukin-3 (IL-3)-dependent growth of an IL-3-
dependent cell line Ba/F3. On the other hand, it drastically inhibited TPO-dependent growth …
