Arginase 1 and arginase 2 variations associate with asthma, asthma severity and β2 agonist and steroid response
JM Vonk, DS Postma, H Maarsingh… - Pharmacogenetics …, 2010 - journals.lww.com
Objectives We investigated the association between arginase 1 and arginase 2
polymorphisms and adult asthma, asthma severity and treatment response in a longitudinal
cohort of 200 asthma patients. Methods Patients were studied during 1962–1975 and
reexamined during 1990–1999, together with their families. Longitudinal data on lung
function and treatment were extracted from medical records. Associations between
haplotype-tagging polymorphisms in arginase 1 (n= 3) and arginase 2 (n= 8) and asthma …
polymorphisms and adult asthma, asthma severity and treatment response in a longitudinal
cohort of 200 asthma patients. Methods Patients were studied during 1962–1975 and
reexamined during 1990–1999, together with their families. Longitudinal data on lung
function and treatment were extracted from medical records. Associations between
haplotype-tagging polymorphisms in arginase 1 (n= 3) and arginase 2 (n= 8) and asthma …